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The Edwards lab conducts research in various aspects of computational biology and bioinformatics, particularly proteomics and mass spectrometry informatics and DNA and protein based signatures for pathogen detection. Research in molecular biology has been revolutionized by the advent of high-throughput experimental protocols that conduct hundreds or thousands of simple experiments in parallel. By itself, each simple experiment means little, but the combined results of all of th.

The quantal release of neurotransmitter underlies information processing by the brain, but the basic mechanisms responsible for this mode of signaling remain poorly understood. What controls the tonic release of neurotransmitter, either by spontaneous vesicle fusion or by non-vesicular efflux across the plasma membrane? What determines the amount of neurotransmitter stored per synaptic vesicle, a poorly understood determinant of quantal size? In addition.